Autoimmune Disease: Why is it important to see if one has any inflammation or an Autoimmune disease

Inflammation is the basis of many diseases. Chronic inflammation leads to scar tissue which leads to the death of cells and organs. Inflammation is also the basis of how cancer cells spread through many molecular pathways, particularly Vascular Endothelial Growth Factor, VEGF, which enables the growth of new blood

The link between autoimmune disorders and lymphoma was first reported in 1966. It is now well known that patients with autoimmune disorders, such as rheumatoid arthritis, Sjögren’s syndrome and systemic lupus erythematosus (LUPUS), present an increased risk of developing lymphoma, particularly non-Hodgkin’s Lymphoma (NHLs). Two large studies confirmed these data noting a 1000 fold increased risk of developing MALT-type lymphoma in patients with Sjögren’s syndrome.

The connection is based mostly on the inflammatory link. 

Thus it is essential to identify patients with Autoimmune diseases and inflammatory conditions.

K. Ekstrom Smedby, C.M. Vajdic, M. Falster, E.A. Engels, O.Martinez-Maza, J. Tuner, et al.Autoimmune disorders and risk of non-hodgkin lymphoma subtypes: a pooled analysis within the InterLymph consortium
Blood, 111 (8) (2008 Apr 15), pp. 4029-4038
E.A. Engels, J.R. Cerhan, M.S. Linet, W. Cozen, Davis S.ColtJS, et al.Immune-related conditions and immune-modulating medications as risk factors for non-hodgkin’s lymphoma: a case-control study
Am J Epidemiol, 162 (12) (2005 Dec 15), pp. 1153-
Shopping Cart