Could new onset dry eye symptoms be associated with ASIA syndrome after COVID vaccine?

My sister who is head of oculoplastics at Stanford asked if I thought if her friend’s acute dry eye syndrome could have been induced by a COVID booster. Her friend thinks her symptoms started 10 days after her COVID booster. 

She asked if it was due to the ASIA syndrome. There is no way to know if the adjuvant of the COVID vaccines are causing an uptick in autoimmune disease we are seeing in kids and adults (ie, Bells Palsy, skin dermatitis [my son had this for 1mo after his first COVID Pfizer shot but there is not way to prove this], new abdominal abscesses, and new cancers). 

Hopefully, the NIH is doing a double blinded, randomized controlled study long term with these new vaccines to see if there is a connection.

For now, all we can do is report this potential association. 
SLC J Rheumatol. 2017 Jun; 28(2): 64–69.Published online 2017 Jun 27. doi: 10.31138/mjr.28.2.64PMCID: PMC7046028PMID: 32185259

The ASIA syndrome: basic concepts

Abdulla Watad,1,2 Kassem Sharif,1,2 and Yehuda Shoenfeld2Author informationArticle notesCopyright and License informationDisclaimerThis article has been cited by other articles in PMC.Go to:


The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. The disease spectrum is heterogeneous in respect to clinical presentation as well as severity of the clinical manifestations. Adjuvants are included in vaccination formulations for their immunogenic properties. Despite being generally well tolerated, safe and effective, some genetically predisposed individuals can develop generalized non-specific constitutional symptoms, autoantibody production, new onset, or worsening of disease presentation. In this review, we focus on the current knowledge presented in the literature on ASIA syndrome, increasing physician awareness about the basic concepts of ASIA syndrome and highlight the devastating amount of data accumulated in the last few years concerning the relationship between various adjuvants and autoimmunity.

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