CyclASol is not FDA approved yet but holds promise.

Below this report, Dr. Hovanesian, notes this exciting new formulation. He does has a vested interest in this company, but it does seem initial results of this new formulation of an old dry eye drug does wok to decrease corneal staining from dry eye.

I have no vested interest in any dry eye company.

Novaliq reports CyclASol for dry eye shows positive topline results

CyclASol 0.1% for dry eye disease showed superiority to vehicle in change from baseline on corneal fluorescein staining in its first pivotal clinical trial, Novaliq announced in a press release.
The phase 2b/3 randomized, double-masked, vehicle-controlled ESSENCE trial included 328 patients at nine U.S. clinical sites and evaluated the primary efficacy endpoint of improvement in total corneal fluorescein staining over vehicle at 4 weeks, with continued dosing over 3 months.
Improvement of total corneal fluorescein staining at day 29 was statistically significant with CyclASol over vehicle (P = .0002), with effects beginning as early as 2 weeks after treatment, the release said.
CyclASol 0.1% is a preservative-free ophthalmic solution of 0.1% cyclosporine A in EyeSol, Novaliq’s water-free technology for ophthalmology.
“These results provide pivotal evidence and a clear direction for Novaliq to pursue a timely completion of the clinical development of CyclASol,” Gabriela Burian, MD,consulting chief medical officer for Novaliq, said in the release.

John A. Hovanesian

John A. Hovanesian
Novaliq’s eye drop platform is quite unique because it is the first topical eye formulation that is water-free. The gentle organic vehicle that delivers cyclosporine in CyclASol has the advantages of being almost imperceptible when it is applied to the eye, having a very small, 10 µL drop size, and being capable of delivering a much higher concentration of this water-insoluble drug than any aqueous vehicle could allow. It also distributes itself over the eye in a super-fine layer that increases the surface area of absorption compared to other vehicles.  And the product requires no preservative.  It is exciting to imagine the different applications of this platform that we will see in the coming years.
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