Doxycycline and Its Role in Dry Eye Treatment and Ocular Rosacea as an Anti-Inflammatory

For years I have written about Doxycycline. I have mentioned how my mentor at Harvard, Dr. Judah Folkman, used to comment that 20mg is the best for decreasing inflammation and that if he could put it in the water, he would. He used to note that a majority of his cancer patients were on 20mg Doxy to help decrease inflammation (and VEGF: see Reference below).

We have used Doxycycline 20mg po qday for years to help decrease eyelid inflammation. It does its job but not everyone notices an improvement in their eye symptoms. A great deal of Meibomian Gland atrophy is due to inflammation at the gland’s orifice which lead to a backlog of oil and ultimate downregulation of the oil production and atrophy.

One of the key questions we have long had is the effect of Doxycyline on gut flora and resistance. A wonderful patient did the research for me and found this article noting 20mg of Doxy does not affect the microbiome which is a key component to general health (see next blog post 😉


More References:

. 2018; 13(1): e0190981.
Published online 2018 Jan 19. doi: 10.1371/journal.pone.0190981
PMCID: PMC5774698
PMID: 29351307

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Mari MerentieData curationFormal analysisFunding acquisitionInvestigationMethodologyProject administrationResourcesSupervisionWriting – original draft,1 Riina RissanenData curationFormal analysisFunding acquisitionInvestigationMethodology,1 Line Lottonen-RaikaslehtoData curationFormal analysisInvestigationMethodology,1 Jenni HuuskoData curationFormal analysisMethodologySupervision,1 Erika GurzelerData curationFormal analysisMethodology,1 Mikko P. TurunenConceptualizationSupervisionVisualization,1 Lari HolappaData curationFormal analysisInvestigationMethodology,1 Petri MäkinenMethodologySupervisionVisualization,1 and Seppo Ylä-HerttualaConceptualizationFunding acquisitionProject administrationResourcesSupervisionVisualizationWriting – original draft1,2,3,*
Anindita Das, Editor

Associated Data

Data Availability Statement

Low dose Doxycycline 20mg per day: Periostat: Is extremely safe. Rare side effect which I have never seen with doxycycline but has been reported at higher levels.

Master QA List:

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