Stromal Vascular Fraction is often created from from Adipose (Fat). SVF contains stem cells which seem to have the potential to create many different cell types depending on the location where the SVF is injected. SVF is used for many other indications. One of the successful indications has been treating the dark circles under one’s eyes.
A good explanation and before and after results for treating “bags under the eyes” is located at: http://stemcellrevolution.com/news-and-events/csn-webinar-series-stem-cells-new-era-medicine/
This webinar does have photos of breast augmentation results so this is not meant to show children.
More and more papers come out each week showing the positive potential of SVF.
The below new article shows the promising results of SVF stem cells to regenerate tendons.
Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: a promising source of tendon progenitor cells.
- 1
- 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho. Avepark – Parque de Ciência e Tecnologia, Barco, GMR, Portugal.
- 2
- ICVS/3B’s-PT Associated Laboratory, Guimarães, Braga, Portugal.
Abstract
Cell-based therapies are of particular interest for tendon and ligament regeneration given the low regenerative potential of these tissues. Adipose tissue is an abundant source of stem cells, which may be employed for the healing of tendon lesions. However, human adult multipotent adipose-derived stem cells (hASCs) isolated from the stromal vascular fraction (SVF) of adipose tissue originate highly heterogeneous cell populations that hinder their use in specific tissue-oriented applications. In this study, distinct subpopulations of hASCs were immunomagnetic separated and their tenogenic differentiation capacity evaluated in the presence of several growth factors (GFs), namely EGF, bFGF, TGF-β1 and PDGF-BB, that are well-known regulators of tendon development, growth and healing. Among the screened hASCs subpopulations, tenomodulin (TNMD+) positive cells were shown to be more promising for tenogenic applications and therefore this subpopulation was further studied assessing tendon-related markers (scleraxis, tenomodulin, tenascin C and decorin) both at gene and protein level. Additionally, the ability for depositing collagen type I and III forming extracellular matrix structures were weekly assessed up to 28 days. The results obtained indicated that TNMD+ cells exhibit phenotypical features of tendon progenitor cells and can be biochemically induced towards tenogenic lineage, demonstrating that this subset of hASCs can provide a reliable source of progenitor cells for therapies targeting tendon regeneration.
