Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfon: may help treat runny nose from Allergic Rhinitis

I am doing more research on MSM pills and drops.

It is interesting I and many surgeon-colleagues have not heard about this option.


Logo of resprot

JMIR Publications JMIR Research Protocols About Search Archive Current Issue Submit Editorial Board
. 2018 Nov; 7(11): e11139.
Published online 2018 Nov 29. doi: 10.2196/11139
PMCID: PMC6293242
PMID: 30497995

Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study

Monitoring Editor: Gunther Eysenbach and Nicola Kuter
Reviewed by Carmi Geller-Bernstein and Kruthika Sundaram
Susan Hewlings, PhDcorresponding author#1 and Douglas S Kalman, PhD#2

Susan Hewlings, Department of Nutrition, Central Michigan University, 1200 S Franklin St, Mount Pleasant, MI,, United States, Phone: 1 321 377 4522,



Allergic rhinitis, or nasal allergy, is an extremely common ailment that occurs when the nasal mucosa undergoes inflammation in response to inhaled allergens []. The prevalence of this condition ranges from 10% to 20% in the United States []. It is characterized by several uncomfortable symptoms: red itchy eyes; a blocked, itching, runny nose (a group of symptoms referred to as rhinorrhea); and sneezing. Other reported symptoms include throat clearing, headaches, facial pain, ear pain, itchy throat and palate, snoring, and sleep disturbances. Severe allergic rhinitis can significantly affect the patient’s quality of life, sleep, and work performance []. Nasal allergy commonly occurs when an individual’s immune system overreacts to allergens such as grass, weed, or tree pollens; house dust; mites; mold; and animal dander [,].
Allergic rhinitis was previously considered to be a disorder localized in the nasal passages, but emerging research indicates that the entire respiratory tract is involved. Close physiological, functional, and immunological relationships exist between the upper (nose, nasal cavity, paranasal sinuses, pharynx, and larynx) and lower (trachea, bronchial tubes, bronchioles, and lungs) respiratory tracts []. Although allergic rhinitis can be considered a simple nuisance in the case of mild symptoms, it has been classified as a chronic disease that should be addressed by a physician []. Allergic rhinitis is also associated with serious inflammatory disorders, including asthma. In fact, 80% of asthmatic patients have allergic rhinitis and 40% of rhinitis patients have asthma [,]. Allergic rhinitis is controlled by various palliative therapies, most commonly antihistamine medications, which often produce sedative side effects [].
Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic compound containing sulfur that occurs naturally in the body, as well as in a variety of fruits, vegetables, grains, and animals []. Orally and topically, it is used to treat chronic and musculoskeletal pain, osteoarthritis, joint inflammation, exercise-induced muscle damage, hemorrhoids, and rosacea []. However, only a few studies have reported the potential benefits of MSM in treating allergic rhinitis and allergic sinusitis [,].
One multicenter human trial found that the consumption of 2.6 g of MSM effectively reduced symptoms of seasonal allergic rhinitis (SAR). This dose of MSM improved the frequency of upper respiratory signs and symptoms such as runny nose, nasal obstruction, and paroxysmal sneezing after a week of oral intake []. However, that study prompted criticism because it lacked quantification of pollen count each participant was exposed to []. In this study, we aimed to address the efficacy of MSM treatment using controlled standardized conditions in healthy participants with a history of SAR.
MSM is considered safe for consumption, as clinical studies have reported few, if any, side effects in a human population []. Moreover, in rats, MSM administered at 2 g/kg, a dose 5 to 7 times the maximum recommended dose for humans, was well tolerated and elicited no adverse events or deaths. No gross pathological lesions or changes in organ weights were observed, and renal history appeared to be normal in treated rats []. Similarly, oral intake of MSM also led to no adverse events in pregnant rats [], suggesting it is safe for consumption even at high doses.


This randomized, double-blind, adaptive-design study aimed to assess the efficacy of the MSM study product in attenuating nasal provocation after exposure to standardized allergens. End points were percentage change in peak nasal inspiratory flow (PNIF) and visual analog scale (VAS) nasal symptom score in response to allergen exposure.
Shopping Cart