This is for a patient who asked what the difference is between PRP and PRGF.
The answer: it appears to be the same.
Platelet Rich Plasma as is typically used by most doctors and surgeon in the US.
The issue is the following:
1. PRP technically is just platelets and not activated with Calcium Chloride (see Ref 1 paper).
2. PRGF is activated PRP which means generally calcium choride was added as noted in below published protocol from Reference 1.
Activated PRP is what is used in the majority of PRP injection cases to my knowledge in the US.
Thus activated PRP is the same as PRGF.
It appears that the authors of the papers on PRGF or Endoret® had a significant vested interest. Either way activated PRP and PRGF do work to help patients with dry eye.
Be sure your surgeon is using activate PRP.
Searching for the best blood-derived eye drops
The Effect of Immunologically Safe Plasma Rich in Growth Factor Eye Drops in Patients with Sjögren Syndrome.
Preservation of Biological Activity of Plasma and Platelet-Derived Eye Drops After Their Different Time and Temperature Conditions of Storage.
PRGF Sample Preparation PRGF eye drops from each donor were obtained using the Endoret-Ophthalmology kit (BTI Biotechnology Institute, SL, Miñano, Álava, Spain).
Plasma rich in growth factors (PRGF) is an autologous platelet-rich plasma based on the use of the patient’s own blood, and the resulting therapeutic formulations derived from this technology contain a wide variety of growth factors, proteins, and biomaterials involved in tissue regeneration. The effectiveness, signiﬁcant clinical advantages, and safety of this approach have been deeply demonstrated in several medical ﬁelds.2–5 In fact, PRGF provides a pool of biologically active proteins and growth factors, including plateletderived growth factor-AB (PDGF-AB), transforming growth factor-b1 (TGF-b1), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), thrombospondin-1 (TSP-1), and angiopoietin-1 (ANG-1) among others. These proteins are involved in a range of biological processes, including cell recruitment, growth, and differentiation.6,7
The authors declare the following competing financial interest(s): E.A. is the Scientific Director of and G.O. and F.M. are scientists at BTI Biotechnology Institute, a dental implant company that investigates in the fields of oral implantology and PRGF-Endoret technology