We have a doctor in the office who has severe dry eyes most likely from years at the computer. She has tried years of warm compresses, lid massaging, more frequent blinking, increased Omega 3, Restasis, Xiidra, punctal plugs of both lower lids.
The objective was to provide preliminary information about the efficacy and safety of immunologically safe plasma rich in growth factor (immunosafe PRGF) eye drops in the treatment of moderate to severe dry eye in patients with primary and secondary Sjögren’s syndrome (SS) and to analyze the influence of several variables on treatment outcomes.
This retrospective study included patients with SS. All patients were treated with previously immunosafe PRGF eye drops to reduce the immunologic component contents. Ocular Surface Disease Index (OSDI) scale, best-corrected visual acuity (BCVA), visual analog scale (VAS) frequency, and VAS severity outcome measures were evaluated before and after treatment with immunosafe PRGF. The potential influence of some patient clinical variables on results was also assessed. Safety assessment was also performed reporting all adverse events.
Twenty-six patients (12 patients with primary SS, and 14 patients suffering secondary SS) with a total of 52 affected eyes were included and evaluated. Immunosafe PRGF treatment showed a significant reduction (P < 0.05) in OSDI scale (41.86%), in BCVA (62.97%), in VAS frequency (34.75%), and in VAS severity (41.50%). BCVA and VAS frequency scores improved significantly (P < 0.05) after concomitant treatment of PRGF with corticosteroids. Only 2 adverse events were reported in 2 patients (7.7% of patients).
Signs and symptoms of dry eye syndrome in patients with SS were reduced after treatment with PRGF-Endoret eye drops. Immunosafe PRGF-Endoret is safe and effective for treating patients with primary and secondary SS.
Finally she tried Platelet Rich Plasma in just her right eye. She said the difference between the two eyes is remarkably improved in the eye she is using PRP after 1 week of treatment.
The literature has confirmed the positive benefit of PRP for Dry Eyes. We just hope this will be a permanent help for her.
J Ocul Pharmacol Ther. 2017 Jun;33(5):391-399. doi: 10.1089/jop.2016.0166. Epub 2017 Apr 4.
The Effect of Immunologically Safe Plasma Rich in Growth Factor Eye Drops in Patients with Sjögren Syndrome.
Sanchez-Avila RM1, Merayo-Lloves J1, Riestra AC1, Anitua E2,3, Muruzabal F2,3, Orive G3,4,5, Fernández-Vega L1.