My dearest friend’s mom died two days ago which has been hard for my friend and her family. She lived a long life, but of course my friend and I have been talking a lot about life and living longer, healthier, and holier.
Today, this video of an interview with Dr. David Sinclair popped up during an exercise routine.
I listened to most of it on double speed and found it very interesting.
Highly recommend. Lent is a perfect time to follow many of his suggestions.
SLC
SLC
Quick notes:
Key points:
Be hungry often during week: fasting is crucial to a long life. OMAD: One Meal a Day Diet goes along with this.
Exercise
Be cold often
Avoid radiation and anything that destroys DNA
What Dr. Sinclair takes:
Resveritrol supplement 98+% pure: from Red Wine: 2003: mimic fasting; 1 teaspon in yogurt in yogurt
Metformin: Dr. Sinclair takes this likely a couple times per week; this is a prescription drug for diabetics so I’m not sure how he got this Rx.
Increase Certullins
NAD booster molecules
NR: nicotine riboside
NMN turns cell into NAD; he takes NMN: https://amzn.to/3dCJSSH
Vitamin D
MRI of Heart
Hot 115F to Sauna to -5C cold;
Avoid radiation, CT scans, xray if can help it as it can break DNA.
Inside Tracker: blood tests: look at 30 parameters in blood; David Sinclair is an investor.
https://www.insidetracker.com/
Suggestions:
$99 Genome Sequence: some variants can project longevity or show mutations
MRI of heart
Horvath clock
Telemere length
Recommendations from this video:
1. at least 2500 Vitamin D per day
2. Keep humidity 35-40% with home humidifier when climate is dry
3. Eat kale, blueberries
4. Fast, keep blood sugar under control
5. Stand as much as possible during day & exercise
https://lifespanbook.com/
twitter: davidasinclair
instagram: davidsinclairphd
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.
Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazine’s list of the “100 most influential people in the world”.
David A. Sinclair’s Past and Present Advisory roles, Board Positions, Funding Sources, Licensed Inventions, Investments, Funding, and Invited Talks.