Stromal Vascular Fraction

Stromal vascular fraction (SVF) is the part of Adipose Tissue (ie, your fat tissue taken out with liposuction usually and is also known as autologous adipose tissue) which has cell components that can potentially regenerate dying or dead tissue.  It is sometimes called also adipose-derived stromal vascular fraction cells


SVF cells contain the cell types:
1. including adipose-derived stem cells (ADSCs)
2. mesenchymal and endothelial progenitor cells
3. leukocyte subtypes
4. lymphatic cells
5. pericytes
6. vascular smooth muscle cells. 


The SVF cells are processed in a way to keep a reproducible and consistent composition of heterogeneous cells that are stable. Upon processing and administration, the adipose-derived SVF cells can differentiate into different tissue types, support neovascularization, replace cells and repair injured issue. 
https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=777203

Adipose tissue has emerged as an attractive cell source in tissue engineering and regenerative medicine because it can be easily collected and enriched with stem/progenitor cell populations. The stromal vascular fraction (SVF) derived from adipose tissue contains heterogeneous cell populations such as mesenchymal progenitor/stem cells, preadipocytes, endothelial cells, pericytes, T cells, and M2 macrophages. SVF-derived mesenchymal progenitor/stem cells can be easily expanded in vitro and have the potential to create diverse lineages of cells. Although there have been issues related to their isolation and purification, SVF cells demonstrate regenerative potential in damaged tissues or organs through paracrine and differentiation mechanisms. Furthermore, SVF cells augment immunological tolerance by promoting inhibitory macrophages and T regulatory cells and by decreasing ongoing inflammation. Numerous implantations of freshly isolated, autologous adipose tissue-derived SVF cells in cosmetic surgeries and in a wide variety of other specialties support the safety of SVF cells and have accelerated their clinical application. Despite these attractive advantages of SVF cells in clinical interventions, to our knowledge the recent status of clinical studies of various diseases has not been fully investigated. 

Stromal vascular fraction

From Wikipedia, the free encyclopedia
Stromal vascular fraction
Stromal Vascular Fraction

Stromal Vascular Fraction
Stromal vascular fraction (SVF) of adipose tissue is a rich source of preadipocytes, mesenchymal stem cells (MSC), endothelial progenitor cell, T cells, B cells, mast cells as well as adipose tissue macrophages.[1][2]

Introduction[edit]

Stromal Vascular Fraction (SVF) is a component of the lipoaspirate obtained from liposuction of excess adipose tissue. Lipoaspirate, the waste product of liposuction (cosmetic surgery), contains a large population of stem cells called adipose derived stem cells (ADSCs), which share a number of similarities with bone marrow stem cells, including the capacity for multilineage differentiation. Autologous SVFs containing ADSCs are currently being used in clinical settings for various orthopedic applications for human patients without any serious side effects.[3] [4]

References[edit]

  1. Jump up

    References[edit]

    1. Jump up^ Riordan, NH; Ichim, TE; Min, WP; Wang, H; Solano, F; Lara, F; Alfaro, M; Rodriguez, JP; Harman, RJ; Patel, AN; Murphy, MP; Lee, RR; Minev, B (Apr 24, 2009).  “Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.”.Journal of translational medicine. 7: 29. 
    2. Jump up^ Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab 2012; 23:407-15.
    3. Jump up^ Pak, J.; Lee, J. H.; Park, K. S.; Park, M.; Kang, L.-W.; Lee, S. H. (2017). “Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications”.  J. Biomed. Sci. 24:9
    4. Jump up^ Pak, J.; Lee, J. H.; Park, K. S.; Jeon, J. H.; Lee, S. H. (2017). “Potential use of mesenchymal stem cells in human meniscal repair: current insights”. Open Access J. Sports Med. 8: 33–38. Open Access J. Sports Med. 8: 33–38. 

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