Updated information about DNAse. We have had now 4 patients who have used DNAse. 3 said it helped. 1 said it did nothing. Where to get DNAse: Hunt Valley, our local compounding pharmacy makes this for our patients and charges about $450 for 8 weeks. The prescription is: DNase 0.1% 4x/day for 8 weeks. This is an FDA approved drug for cystic fibrosis and not dry eye so insurances do not make it. We have had no complications. Dr. Jain has not reported any complications either. SLC
This is for some patients who are stuck at home and cannot come in to discuss new Dry Eye options. We have treated 3 patients with DNase with good results. 2 of the 3 did not have Sjogren’s or any other underlying issue. I spoke to Dr. Jain directly before putting my first patient on DNase. He said DNase had a safe risk profile to help with eye inflammation and dry eye pain. It is not a cure but another option. Right now, during the pandemic, it might be hard to get.
To discuss more with me, please call 2407060313 to make an appointment to discuss this medication (drop) and how to get it.
Sandra Cremers, MD, FACS
Clinical Trials | May 2019
A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease
Volume 18, Issue 1
, January 2020, Pages 80-97