However, there may be genetic mutations we could correct in near future for other important causes and risk factors for dry eyes: We are still looking for the gene that causes these disease in many cases below but most researchers strongly believe there are genetic components to each below:
1. Certain Cancers especially on the surface of the eye
2. Sjogren’s syndrome
6. Ehlers-Danlos Syndrome: I have 3 patients with severe MGD who have EDS: never been published the relationship: are there any pre-med students out there that want to help with this paper?
7. Dry Eye—-itself (see Reference 1 below)
8. Rheumatoid Arthritis: we hope to publish a paper showing how RA can destroy meibomian glands.
10. Any autoimmune disease
11. Isotretinoin damage: this has not at all been studied, but I believe that those patients who experience devastating dry eyes from isotretinoin may be genetically predisposed as there are also many patients who do not have any issue with its use for years. I do think this drug should be banned globally. Still there are other factors involved that make its use devastating and others have no issues: why does this happen? No one knows currently, but there is likely a genetic component even if small.
Diseases that have a genetic mutation can also benefit from stem cell therapy it appears. In the future for these cases, scientists could hopefully correct the genetic mutation before it takes effect in the adult stem cell and/or use adult stem cell therapy to correct any issues.