Treatment Options for Dry Mouth
Many of my patients have dry mouth in addition to dry eyes.
The best options for dry mouth treatment are below. They each have their risks so be sure to understand risks before taking them.
3. Interferon -α
Systemic Salivary Stimulation
This is a medication some of my patients says helps their dry mouth from Sjögren’s syndrome. The biggest risk is angle closure risk due to the mechanism of action. I have not seen anyone have this from this medication but it can happen.
|By mouth (capsules)|
|Chemical and physical data|
|Molar mass||199.31308 g/mol|
|3D model (JSmol)|
|(what is this?)|
Cevimeline (trade name Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M1 and M3 receptors. It is used in the treatment of dry mouth and especially associated with Sjögren’s syndrome.
Mechanism of action
By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.
Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.
- Pilocarpine — a similar parasympathomimetic medication for dry mouth (xerostomia)
- Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting effect