Anti-Cancer Diet: Your Risk of Developing Cancers, Metastasis, and other Diseases dependent on Angiogenesis & Your Angiogenic Risk Profile (ARP)

Anti-Cancer Diet: 
Your Risk of Developing Cancers, Metastasis, and other Diseases dependent on Angiogenesis & 
Angiogenic Risk Profile (ARP)

Research by Dr. Judah Folkman and others at Harvard Medical School and throughout the world has identified angiogenesis as an underlying etiology for many cancers and other diseases. Angiogenesis is the process by which factors are released by a cancer to make new blood vessels grow towards the cancer to allow the cancer to grow and spread. There is a hypothesis that the more angiogenic growth factors that are circulating in your body, the more likely one is to have cancer and metastasis. 
We worked on the idea of a Risk Profile for Angiogenesis or Angiogenic Risk Profile (ARP).

The idea here is that some people or families may have genetic and environmental factors that increase the risk of angiogenesis in the body.

Here are some factors we have been looking into. Namely I have been studying Ocular Rosacea and the association between severe Ocular Rosacea and Wet Macular Degeneration, Proliferative Diabetic Retinopathy, and metastatic solid internal tumors (all disease dependent on angiogenesis).

1. Some people have genes that predispose them to easily reved-up VEGF and other angiogenic factors. We know that Downs syndrom patients have an extra copy of chromosome 21 and extra anti-angiogenic genes/proteins.

1. Diet: One’s diet is crucial in protecting one from mutations, angiogenesis, cancer, metastasis. Excessive sugars, carbohydrates, red meats, fats likely induce cell death and increase inflammation and angiogenesis in the body. Anti-oxidants, vast omega 3s in a diet decrease angiogenesis (extensive list below). Self imposed fasting from meats and other proteins like eggs, chicken help the body avoid angiogenic factor genesis.

The issue of a “CANCER DIET” is very controversial. For years there have been many physicians who have many case reports of patients who have been miraculously cured from special “Cancer Diets.” While I am all for trying to cure cancer naturally, the fact remains is that we do not have yet great randomized, prospective, double blinded studies. Nor will we have any in the near future as it is so hard to control for all the many environmental different patient’s experience day to day. Here is more on the potential for a “Cancer Diet” and its controversies:

2. Toxins: The number one culprit is smoking: an acute mutation inducer!
3. Sun: in moderation, sun exposure is good for vitamin D exposure (which helps fight infections); but in excess and especially in young kids, excessive sun exposure damages young genes and can lead to angiogenesis inducers likely.
4. Radiation (in all its various manifestations); directly induces mutations in cells
5. Infections: bacterial & viral & fungal; can increase angiogenesis in the body

1. Exercise: regular exercise is imperative to weight control and decreasing one’s angiogenic risk profile.
2. Finding Peace: Meditation and Prayer. Though this is the least researched area of life, there is likely a factor or protein produced when one is in a state of peace. Stress, anxiety, depression, anger, a sense of hopelessness (no matter what life throws at you: though easier to say than do, it can be true:) increase stress factors which increase angiogeneic factors.

Known Measurable Factors that indicate Potential Increased Angiogenic Risk:
1. ESR: Sedimentation rate
2. Cholesterol Level: specifically LDL
3. Smoking History: Pack Year History
4. MMP-9: new diagnostic tool; now using for measuring MMP-9 in tears
5. HgA1C: standard measure of blood glucose levels for patients at risk for diabetes 
6. Circulating Endothelial Cells

Other factors that likely add to one’s Angiogenic Risk Profile.
1. Blood pressure
2. History of toe fungus
3. Presence of Diabetic Retinopathy
4. History of Atherosclerotic heart disease

Best Cancer Diet Theoretically: Eating a moderate amount of the below items, particularly the veggie & spices items (avoid excessive fruit intake as too much fruit sugar or fructose, could increase your angiogenic risk profile and definitely increase your risk of Diabetes).
These items are known to decrease one’s Angiogenic Risk Profile:

I. Diet: 
a. Green tea
b. Strawberries
c. Blackberries
d. Rasberries
e. Blueberries
f. Oranges
g. Grapefruit
h. Lemons
i. Apples
j. Pineapple
k. Cherries
l. Red Grapes
m. Red Wine
n. Bok Choy
o. Kale
p. Soy beans 
q. Ginseng
r. Mitake mushrooms
s. Licorice
v. Artichokes
w. Lavender
x. Pumpkin
y. Sea Cucumber
z. Tuna
1. Parsley
2. Garlic
3. Tomato (in all forms)
4. Olive Oil
5. Grape seed oil
6. Dark chocolate
7. Pomegranate (my absolute favorite!)
II. What to Avoid:
1. avoid all refined sugar
2. avoid all refined carbohydrates: bread, pasta, cake
3. This is very controversial but many cancer doctors are now recommending one avoid red meat and just eating wild, low mercury fish.
4. Also controversial but recommended: eat only organic; avoid gluten.
III. Exercise:
1. This also is a bit controversial in cancer patients. The Gerson Diet doctors recommend avoiding exercise to help the body fight the cancer. This does not make absolute sense to me, but again there are few studies on this subject. It seems to me that some exercise is good for the body, but I cannot prove that to be true for cancer patients based on published reports.
IV. Sunlight:
1. Sunlight naturally increases a body’s Vitamin D levels. But avoid excess sunlight for the purposes of the increased risk of melanoma. 

Though I have yet to publish on the following fact, I am convinced a good examination of one’s eyes under the microscope helps in the calculation of one’s angiogenic risk profile. 

Under the microscope we can see all the small blood vessels not only in the retina and on the optic nerve, but also on the cornea, conjunctiva, and especially along the eyelid margin. What we see going on in the blood vessels of the eye under the microscope, is an indication of what is going on inside the body.

Another good explanation of diet and decreased cancer risk is Dr. Andrew Li who was the student of Dr. Folkman for years. His excellent video is below.

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