Exosomes and Dry Eye Disease: its Role in Regenerative Medicine

Exosomes have become a better-understood cellular vehicle or vesicle to help stimulate the body’s regenerative properties. These little vesicles are extracellular vesicles (EVs) with a diameter of about 40-100nm which are produced in the endosomal compartment of most eukaryotic cells. They are composed of lipids, proteins, mRNA, and miRNAs which appear to work to stimulate the body’s own progenitor cells.

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Artificial Tear Recommendation

Many of my patients have tried hundreds of different artificial tears. The only drop that was shown to be superior in a study, not sponsored by the company, was RETAINE. But I have many patients who really get more eye irritation with Retaine. The key issue is to avoid Preservatives as these are a concern

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New Additions to Dry Eye Regimen: Will be adding them to my Step Ladder.

New Dry Eye Products are coming to market faster than ever. Cequa (Cyclosporin 0.09%) was just FDA approved and released on the market 2 weeks ago. Cequa hopes to take down Restasis (Cyclosporin 0.09%) as a more comfortable Cyclosporin drop without the side effects with Cequa’s nanomicelles technology which encapsulates the cyclosporin molecule. Still about

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Systemic Absorption of Retina A Cream into Body

These types of studies are frustrating as they are sponsored by the drug company that makes Retina A cream. Still looking for unbiased studies. SLC J Clin Pharmacol. 1997 Apr;37(4):279-84. Negligible systemic absorption of topical isotretinoin cream: implications for teratogenicity. Chen C1, Jensen BK, Mistry G, Wyss R, Zultak M, Patel IH, Rakhit AK. Author information 1 Department of Clinical Pharmacology, Hoffmann-La

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Tacrolimus Ointment can Cause an Allergic Dermatitis: It is Often Used for Atopic Dermatitis

Tacrolimus is often prescribed for T cell-mediated diseases such as: 1. eczema or atopic dermatitis 2. psoriasis 3. Vitiligo Orally Tacrolimus is used to: 1. prevent organ rejection 2. Uveitis after Bone Marrow transplantation 3. Minimal change disease of the kidney 4. Kimura’s disease Tacrolimus inhibits the production of interleukin-2, a molecule that promotes the development and proliferation of T cells,

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Acitretin (Soriatane) is a retinoid, which is a form of vitamin A.

Acitretin is a retinoid, which structurally similar to Accutane– which is known to cause severe meibomian gland dysfunction. I could not find a paper stating Acitretin causes meibomian gland issues but there has been no study to evaluate “acitretin’s long term effect on meibomian and lacrimal glands.  Acitretin can cause dry eyes and dryness of the mouth, nose, and throat according

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